Grape Seed Extract Down-modulates Oxidative and Inflammatory Responses of Oral Mucosa Cells
Background: Proanthocyanidins (PAs) are bioflavonoids extracted from seeds and fruits that act as cross-linkers in collagen molecules and act as matrix metalloproteinase (MMP) regulators. Therefore, the use of these compounds seems to be a potential adjunctive therapy for traditional periodontal treatment. This study investigated the potential of PAs extracted from grape seeds (grape seed proanthocyanidins extract – GSPE) to modulate the oxidative and inflammatory response of oral mucosa cells. Materials and methods: Non-cytotoxic concentrations of GSPE were selected for oral...
Autores: Villas Boas SB, Sousa LS, Cardoso LM, Tavella-Silva NC, de Souza Costa CA, and Basso FG,
Aims: The present systematic review and meta-analysis aimed to evaluate the long-term efficacy of periodontal regenerative procedures for the treatment of intrabony periodontal defects after at least 5 years of follow-up. Materials and methods: Electronic literature database search was performed in CINAHL, EMBASE, PubMed, and Web of Science. Additionally, a manual search of literature was performed. Studies conducted in human subjects with intrabony periodontal defects treated using...
Aims: To determine the effect of melatonin supplementation on alveolar bone metabolism in rats with periodontal disease (PD) and pinealectomy. Materials and methods: Eighty rats were distributed into 8 groups: control (CN); pinealectomized (PNX); PD; pinealectomized with PD (PNXPD); control with melatonin (CNMEL); PD with melatonin (PDMEL); pinealectomized with melatonin (PNXMEL); pinealectomized with PD and melatonin (PNXPDMEL). After 20 days of pinealectomy, PD was induced and the...
Aims: To investigate the impact of periodontal therapy on oral health-related quality of life (QoL) measures (OHRQoL) in patients with periodontitis and diabetes. Materials and methods: Patients with stages III and IV, generalized, grades B and C periodontitis and diabetes were assessed for OHRQoL using the Oral Health Impact Profile (OHIP)-14 at baseline and after 6 months of periodontal therapy. The patients were randomly selected to receive placebo after periodontal debridement (n=29), omega...
Aims: The purpose of the study was to examine the gingival tissue mRNA and protein expression of heat shock protein (HSP) 60 and HSP70 in generalized chronic periodontitis (GCP), generalized aggressive periodontitis (G-AgP) and individuals with periodontal health (PH). Materials and methods: Gingival tissue biopsies were acquired from 39 patients with G-CP (n=39), G-AgP (n=37) and PH (n=15). Localization and mRNA expression of HSP60 and HSP70 were evaluated by immunohistochemistry and...
Aims: To assess the effects of different nutritional and atmospheric conditions on the density and bacterial diversity of ex vivo biofilms of individuals with advanced periodontitis. Materials and methods: Subgingival biofilm samples were collected from volunteers with advanced periodontitis and immediately sent for cultivation of ex vivo biofilms. The biofilms were cultured in Brain Heart Infusion (BHI) + 1% hemin + 5% sheep blood or in BHI + 5% bovine serum; under anaerobic or capnophilic...
Aim: The aim of this report was to describe the phenomenon of creeping attachment that occurred following the use of a new xenogenic collagen matrix (CMX) for the treatment of multiple recession defects in the aesthetic region. Methods: Two patients with multiple gingival recession defects were treated with coronally advanced flap technique plus CMX (Mucoderm®). Results: Three months after grafting, the amount of root coverage obtained was partial. After a 2-year period, the previously...
Aim: This case series aimed to evaluate the 6-month outcome of the use of a xenogeneic acellular dermal matrix (XDM) associated with the coronally advanced flap (CAF) technique for the treatment of single gingival recession defects (GR) . Materials and methods: Ten patients presenting single GR RT1 (mean 3.5 ± 0.5 mm) were included. Bleeding on probing (BoP), probing depth (PD), clinical attachment level (CAL), gingival recession depth (GRD), keratinized tissue thickness (KTT), keratinized...
Aims: To evaluate the efficacy of ozone therapy as an adjunct to non-surgical periodontal therapy. Materials and methods: Randomized clinical trials that used any form of ozone therapy as adjuvant to nonsurgical periodontal therapy were included. MEDLINE-PubMed, Embase and Scopus databases were searched to identify these studies. Three different meta-analyses were conducted for reduction of probing pocket depth (PPD), clinical attachment (CAL) gain and reduction of bleeding on probing (BoP)....
Aim: Evidence for the treatment of lingual recession defects is scarce. The aim of this case series was to investigate the clinical efficacy of modified coronally advanced tunnel (MCAT) technique in combination with connective tissue graft (CTG) for the treatment of multiple lingual gingival recessions. Materials and methods: Six patients with a total of 20 adjacent RT1 and RT2 lingual recession defects in mandibular incisors were treated with MCAT + CTG. Clinical parameters were recorded at...
Aims: Physical activity (PA) may reduce periodontitis, but most studies have used nonvalidated methods to quantify PA and were conducted with Asian samples. This study assessed the association between PA, periodontitis and calculus in adults. Materials and methods: 285 individuals participating in a population-based cohort study were analyzed. Probing depth (PPD) and clinical attachment loss (CAL) were recorded. PA was assessed by the International Physical Activity Questionnaire (IPAQ)...
Background: Proanthocyanidins (PAs) are bioflavonoids extracted from seeds and fruits that act as cross-linkers in collagen molecules and act as matrix metalloproteinase (MMP) regulators. Therefore, the use of these compounds seems to be a potential adjunctive therapy for traditional periodontal treatment. This study investigated the potential of PAs extracted from grape seeds (grape seed proanthocyanidins extract – GSPE) to modulate the oxidative and inflammatory response of oral mucosa...
Aims: To evaluate the antimicrobial activity of an iodoform-based paste applied to the surface of three types of implant-abutment connections. Materials and Methods: 45 dental implants were used, of which 15 were with Morse Cone tapered (MT), 15 internal hexagon (IH) and 15 external hexagon (EH) connections. Five implants from each of the connection were distributed into three groups according to the antimicrobial material used control group (GC), chlorhexidine (CX) and iodoform paste (PH)....
