Probiotic Lactobacillus Rhamnosus GG Protects Against P. Gingivalis And F. Nucleatum Gut Dysbiosis
Objectives: This study investigated changes induced by Porphyromonas gingivalis and on gastrointestinal histology and gut microbiome in a mouse model of experimental periodontitis. The effect of probiotic Lactobacillus rhamnosus GG (LGG) in altering these changes was also investigated. Methods: Thirty-six mice were allocated into six groups. Experimental alveolar bone loss was induced by oral inoculation with P. gingivalis and F. nucleatum. LGG was orally inoculated or orally gavaged. Gastrointestinal tissue changes were assessed using histological analysis and immunohistochemistry. Caecal...
Autores: P. Mark Bartold, Simona M Gatej, Richard Bright, Laura S Weyrich, Victor Marino, Claus T Christophersen, Rachel J Gibson, Neville Gully, Peter Zilm,
Objective: The aim of this study was to evaluate the association between depressive disorders and periodontal condition and the recurrence of periodontitis, during periodontal maintenance therapy (PMT). Methods: From a 6-year prospective cohort study with 268 individuals under PMT, 124 individuals had complete periodontal clinical data recorded between T1 (baseline) and T2 (final data at the last PMT appointment). Individuals were divided into two groups, being 35 individuals with depressive...
Objectives: To evaluate periodontal parameters of abutment teeth and interproximal sites, in patients with mandibular class I Kennedy Removable Partial Dentures (RPD), after 4 years of periodontal treatment. Methods: Fourteen patients with periodontal disease were treated and evaluated for the following parameters: plaque index (PI), bleeding on probing (BOP), probing depth (PD), gingival recession (GR), clinical attachment loss (CAL) and keratinized mucosa (KM). Parameters were compared...
Objectives: This study investigated changes induced by Porphyromonas gingivalis and on gastrointestinal histology and gut microbiome in a mouse model of experimental periodontitis. The effect of probiotic Lactobacillus rhamnosus GG (LGG) in altering these changes was also investigated. Methods: Thirty-six mice were allocated into six groups. Experimental alveolar bone loss was induced by oral inoculation with P. gingivalis and F. nucleatum. LGG was orally inoculated or orally gavaged....
Background and objectives: Applications of porous titanium granule (PTG) in periodontal (furcation defects) and non-periodontal treatments have shown promising results. However, its role in periodontal intrabony defects still remains unexplored. Thus, we aim to assess the feasibility of PTG in obtaining reconstruction in intrabony defects and compare the outcome with that of open flap debridement (OFD). Method: Ten patients (three females and seven males) with a mean age of 34.7 years who...
The selection of proper outcome measures is a critical step in clinical research. Most randomized clinical trials (RCTs) assessing the effects of initial anti-infective periodontal therapies use surrogate outcomes as primary outcome variables, such as mean changes in probing depth (PD) or in clinical attachment. However, these parameters do not reflect disease remission/control at patient level, which has led to subjective interpretations of the data from RCTs and Systematic Reviews. Based...
