Artigo: Effect of Local Nifedipine Administration on Rat Gingiva - JIAP v14n01 - DentalGO

JIAP v14n01

JIAP v14n01


Effect of Local Nifedipine Administration on Rat Gingiva

Artigo

Background: Nifedipine, a calcium channel-blocking agent, has been associated with gingival enlargement in humans. This enlargement has also been successfully established in animal models. Previous investigators have administered nifedipine through a systemic route, most commonly by oral intake. The aim of the present study was to measure the effects of nifedipine administered directly into rat gingival interproximal papillae. Methods: Twenty-four adult female rats were assigned to three groups. Each animal received a series of three injections, one week apart; each injection was placed...

Autores: Davide Bencivenni, Mirdza E. Neiders, Sebastiano Andreana, Michelle L. Moffitt, Robert E. Cohen, 

ARTIGO ANTERIOR
Histological Evaluation of Osseous Defects Combined with Orthodontic Tooth Movement
Histological Evaluation of Osseous Defects Combined with Orthodontic Tooth Movement

Background: Nifedipine, a calcium channel-blocking agent, has been associated with gingival enlargement in humans. This enlargement has also been successfully established in animal models. Previous investigators have administered nifedipine through a systemic route, most commonly by oral intake. The aim of the present study was to measure the effects of nifedipine administered directly into rat gingival interproximal papillae. Methods: Twenty-four adult female rats were assigned to three...

Regenerative Therapy of Osseous Defects Combined with Orthodontic Tooth Movement
Regenerative Therapy of Osseous Defects Combined with Orthodontic Tooth Movement

Background: Combined orthodontic/regenerative therapy can resolve complex clinical problems and enhance bone formation. The purpose of this study was to evaluate the effectiveness of different times of initiating the active orthodontic tooth movement on the regenerative potential of the intrabony defects. Methods: Fifteen adult patients with at least three intrabony defects and malocclusion were included. A total of 45 defects were divided into three groups and treated in a split mouth...

Effect of Local Nifedipine Administration on Rat Gingiva
Effect of Local Nifedipine Administration on Rat Gingiva

Background: Nifedipine, a calcium channel-blocking agent, has been associated with gingival enlargement in humans. This enlargement has also been successfully established in animal models. Previous investigators have administered nifedipine through a systemic route, most commonly by oral intake. The aim of the present study was to measure the effects of nifedipine administered directly into rat gingival interproximal papillae. Methods: Twenty-four adult female rats were assigned to three...